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2023 · Paper 1 · Question 4 · 9 marks

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4.1

Explain why the damage to the cells lining the ileum reduces absorption of the products of digestion and why this reduces absorption of water.

3 marks
4.2

Not all patients in hospital with C. difficile develop diarrhoea.

Scientists measured the anti-toxin antibody concentration in hospital patients with and without C. difficile infection.

They measured the anti-toxin antibody concentration four times:

• on admission to hospital (day 0) • on day 3 • on day 6 • on the day the patient left the hospital.

Figure 4 shows the scientists' results.

The scientists suggest that the anti-toxin antibody could be given to some patients as a form of passive immunity.

Use Figure 4 to suggest how this passive immunity would work and which patients should be offered this anti-toxin antibody.

Figure 4 is in the question paperFigure for 4.2
3 marks
4.3

To be used as passive immunity treatment, the anti-toxin antibody would be injected. If it was given by mouth, it would be digested.

Describe how the anti-toxin antibody would be digested.

3 marks